Abstract
PURPOSE: Severely myopic eyes have been associated with high posterior capsule opacification (PCO) incidence. Although it has been reported that myopic eyes have weaker or more delayed capsule adhesion than emmetropic eyes, it is unclear whether/how dioptric power and posterior curvature of IOLs affect IOLs' affinity for the posterior lens capsule (PLC) and their PCO potential. METHODS: To investigate this, acrylic foldable IOLs with increasing dioptric power of 6.0D (for high myopia), 20.0D, and 30.0D (for low/non-myopia) were tested on their binding affinity toward PLC and their ability to inhibit the proliferation and infiltration of lens epithelial cells (LECs) using an in vitro simulated human PLC (sPLC) model. RESULTS: We found that IOL power and posterior radius of curvature (PRC) had significant impacts on IOL/sPLC adhesion forces, which are in the following order: 20.0D ≈ 30.0D > 6.0D. Optical coherence tomography (OCT) images showed that loose binding between 6.0D IOLs and sPLC contributed to larger interface spaces and significantly greater LEC infiltration, proliferation, metabolic activity, and transdifferentiation compared to 20.0D and 30.0D IOLs. Statistical analyses showed that IOLs' PRC may have a substantial influence on IOL/sPLC physical interactions, LEC responses, and PCO incidence. CONCLUSIONS: The overall results suggest that the high PRC of low-diopter (6.0D) IOLs reduces their binding affinity toward the PLC, facilitates LEC reactions, thus causes high PCO incidence in myopic eyes. These findings strongly support that a new design to increase IOL posterior surfaces' PLC affinity may reduce PCO potential and increase safety for myopic patients.