A Cross-sectional Study for the Correlation of Vitamin D Level and Severity of Early Rheumatoid Arthritis

维生素D水平与早期类风湿性关节炎严重程度相关性的横断面研究

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Abstract

BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory multisystemic disorder that can cause significant deformity and disability. Vitamin D has a role in Th1-medicated autoimmune diseases like RA. Furthermore, some observational studies have concluded that Vitamin D supplementation reduces the severity of RA. AIMS: This study aimed to find out any correlation between Vitamin D levels and severity of early RA. SETTINGS AND DESIGN: This study settings and design were a cross-sectional single-center observational study. MATERIALS AND METHODS: This was an observational study. All patients with early RA were screened and evaluated as per protocol. No extra tests were done. STATISTICAL ANALYSIS USED: Pearson's Chi-square test for independence of attributes/Fisher's exact test was used to find the association between the categorical variables as appropriate. RESULTS AND CONCLUSION: We found that all patients of early RA had moderate-tosevere disease activity without any relation with their Vitamin D level ( P > 0.05).

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