Selective Mono- and Diamination of 2,6-Dibromopyridine for the Synthesis of Diaminated Proligands

2,6-二溴吡啶的选择性单胺化和双胺化反应用于合成双胺化前体配体

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Abstract

Selective mono- or diaminations of 2,6-dibromopyridine were performed using microwave irradiation with water as solvent in 2-2.5 h. The only significant difference between the syntheses was the inclusion of K(2)CO(3) as base and CuI/DMPAO catalyst for the diaminations. The mono- and diaminations had approximately 7 and 2 g isolated yields, respectively. The monoaminated bromopyridines were attached to a TREN scaffolding molecule yielding novel ligands to support extended metal atom chain complexes.

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