Abstract
Hypoxia leads to increased purine metabolism in tissues, resulting in increased serum uric acid levels, and may also cause impaired uric acid excretion in the kidneys and intestinal tract. However, the relationship between hypoxia and serum uric acid levels in patients with heart failure remains largely unexplored. Because mixed venous oxygen saturation is an acute indicator of systemic oxygenation, in this study, we investigated the relationship between mixed venous oxygen saturation and serum uric acid levels. This retrospective analysis included 386 patients with heart failure who underwent cardiac catheterization at our institution. The relationship between mixed venous oxygen saturation and serum uric acid levels was examined by single regression analysis. Stratified regression analysis, structural equation modeling, and partial correlation analysis were used to examine the effects of eight factors known to influence mixed venous oxygen saturation and serum uric acid levels. The single regression analysis showed a significant negative correlation between mixed venous oxygen saturation and serum uric acid levels (P<0.001). Significant negative correlations were also observed in many subgroups in the stratified analysis, in the path diagram based on structural equation modeling, and in the partial correlation analysis. These results suggest that there may be a direct relationship between mixed venous oxygen saturation and serum uric acid levels that is not mediated by any known factor.