Abstract
Subacute sclerosing panencephalitis (SSPE), slowly progressive neurological disorder, commonly affects children who had past history of measles or if their parents forgot to provide measles vaccination. All cases with simultaneous psychiatric and neurological features with progressive deterioration of intellectual functioning were evaluated with routine blood investigations, magnetic resonance imaging, electroencephalography (EEG), cerebrospinal fluid (CSF) examination, and so on, to rule out mimics. The cases meeting the diagnostic criteria of SSPE are analyzed retrospectively. The clinician should consider SSPE in cases with comorbid neurological and psychiatric features after excluding the common causes, and neuroimaging, EEG, and CSF study are must.