Morphea Induced by Golimumab in a Patient With Ankylosing Spondylitis: A Case Report and Literature Review

强直性脊柱炎患者使用戈利木单抗诱发硬皮病:病例报告及文献综述

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Abstract

Morphea is a localized autoimmune fibrosing disorder that may paradoxically develop during anti-TNFα agents in ankylosing spondylitis (AS). We report a second case of morphea associated with long-term golimumab use in a patient with AS, presenting with indurated plaques and confirmed histopathologically. This case highlights the importance of clinical vigilance and timely dermatologic assessment to determine whether morphea represents a drug-induced reaction or an extra-articular manifestation of AS.

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