New insights in regulation of RAS isoforms revealed by protein structures

Leucine zipper-like post translational regulator 1 (LZTR1) functions as a RAS degrader, but the molecular basis of LZTR1-RAS regulation has remained unclear. A recent report by Dharmaiah et al. presents crystal structures of the LZTR1 Kelch domain bound to RIT1, MRAS, or KRAS, providing the first atomic-level insights into LZTR1 substrate recognition.