Abstract
The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) signaling pathway plays a crucial role in the regulation of fibrosis, a pathological process characterized by excessive deposition of extracellular matrix components leading to tissue scarring and dysfunction. Traditional Chinese medicine (TCM) has been increasingly recognized for its potential therapeutic effects in fibrosis by targeting various signaling pathways, including the PI3K/AKT pathway. This review aims to summarize the recent advancements in TCM interventions targeting the PI3K/AKT signaling pathway for the regulation of fibrotic diseases. Recent studies have explored the potential of TCM in the prevention and treatment of fibrotic diseases, particularly through the modulation of the PI3K/AKT signaling pathway. To gather information on TCM and the PI3K/AKT pathway, an extensive search was conducted across various scientific databases, such as Google Scholar, Web of Science, Scifinder, Baidu Scholar and PubMed. TCM has demonstrated unique potential in managing fibrotic diseases through the modulation of the PI3K/AKT signaling pathway. About 37 types of TCM monomers, 68 species of extracts and related compounds, and 50 types of TCM formulas. It discusses their treatment effects on fibrosis in various organs by regulating the PI3K/AKT pathway. The current advancements in TCM interventions targeting the PI3K/AKT pathway offer novel perspectives and strategies for the management of fibrotic diseases. TCM has shown positive effects in treating fibrotic diseases.