Abstract
INTRODUCTION: Plasma cell rich-acute rejection (PCAR) is a variant of T-cell-mediated rejection in kidney transplantation. Its pathogenesis remains unknown and it is often refractory to standard immunosuppression strategies, possibly leading to allograft loss. Here, we report a case of chronic active T-cell-mediated rejection caused by PCAR 12 years after kidney transplantation. CASE PRESENTATION: A patient first visited our outpatient clinic with hematuria and proteinuria at the age of 23. He was followed as an outpatient for suspected chronic glomerulonephritis, but his kidney function gradually deteriorated and hemodialysis was initiated at age 50. ABO-compatible kidney transplantation was performed at 51. His graft function was stable for 11 years post-transplant with a serum level of creatinine of 1.5 mg/dL. Twelve years post-transplant, however, his graft function worsened to a creatinine level of 3.2 mg/dL, and he was admitted to our hospital for an allograft biopsy. The histopathology showed edematous lesions with massive tubulointerstitial plasma cell infiltration, and severe tubulitis, consistent with chronic active T-cell-mediated rejection type 1B according to the Banff classification 2019. He was treated with steroid pulse therapy (methylprednisolone 1,000 mg for 3 consecutive days), and his graft function improved to a creatinine level of 2.2 mg/dL. A repeat allograft biopsy 3 months after the steroid therapy showed improved interstitial edema and tubulitis. CONCLUSION: As suggested in this case, it is still possible to achieve a favorable response by initiating appropriate treatment in early stages of PCAR.