Preoperative administration of eculizumab to prevent surgery-triggered hemolysis during cesarean section with paroxysmal nocturnal hemoglobinuria

术前使用依库珠单抗预防剖宫产术中阵发性睡眠性血红蛋白尿引起的手术诱发溶血

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作者：Li,Dongping,Wang,Liangcheng,Horiuchi,Isao,Kimura,Shun-Ichi,Chikazawa,Kenro,Kimura,Azusa,Sasaki,Shigetane,Kuwata,Tomoyuki,Takagi,Kenjiro
期刊：Clinical Case Reports影响因子：0.600
时间：2018起止号：2018 Sep;6(9):1807-1809
doi：10.1002/ccr3.1707

Abstract

Eculizumab in pregnancy has been reported to be effective in improving outcomes in patients with paroxysmal nocturnal hemoglobinuria. However, a cesarean section may result in surgery-triggered hemolysis. An additional dose of eculizumab just prior to delivery is an appropriate choice to prevent postoperative hemolysis.

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