Recent Advancement in H(8)-BINOL Catalyzed Asymmetric Methodologies

H(8)-BINOL催化不对称合成方法的最新进展

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Abstract

H(8)-BINOL, a partially reduced form of BINOL, is widely employed in a broad array of organocatalyzed asymmetric methodologies. Over the last 25 years, asymmetric organocatalysis has witnessed an incredible improvement, and an advancement still continues to get a single enantio-enriched product. The broad-spectrum applications of H(8)-BINOL organocatalyst in C-C bond formation, C-heteroatom bond construction, name reactions, pericyclic reactions, and one pot and multicomponent reaction are attracting the attention of researchers. A diversified unique H(8)-BINOL-based catalyst has been synthesized and screened for catalytic activity. In this Review we frame out the H(8)-BINOL catalyzed novel discoveries from the last two decades.

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