Abstract
Peroral endoscopic myotomy (POEM) has revolutionized the treatment of upper gastrointestinal tract motility disorders, particularly achalasia. This editorial explores the efficacy, safety, and challenges of POEM, emphasizing its role as a primary treatment with excellent long-term outcomes and minimal adverse events. The evolution of POEM underscores the need for precision in myotomy techniques and the importance of interdisciplinary collaboration, especially regarding anesthetic considerations. Despite significant advances, challenges remain in standardizing safety protocols and managing complications. As POEM applications expand, precision endoscopy continues to enhance therapeutic outcomes, promising a transformative impact on gastrointestinal motility disorder management.