On the Path from Proteomics to Function: GABA(A)R Trafficking Takes a Turn

There are significant challenges in identifying receptor-specific functional interactors in vivo. In this issue of Neuron, Ge et al. (2018) identify a novel GABA(A) receptor (GABA(A)R)-interacting protein, Clptm1, that regulates forward trafficking of GABA(A)Rs and inhibitory transmission.