Imaging of Activated T Cells as an Early Predictor of Immune Response to Anti-PD-1 Therapy

活化 T 细胞成像作为抗 PD-1 疗法免疫反应的早期预测指标

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作者:Jelena Levi, Tina Lam, Samuel R Goth, Shahriar Yaghoubi, Jennifer Bates, Gang Ren, Salma Jivan, Tony L Huynh, Joseph E Blecha, Roli Khattri, Karl F Schmidt, Dominique Jennings, Henry VanBrocklin

Significance

These findings reveal differences in T-cell activation between responders and nonresponders early into anti-PD-1 treatment, which may impact many facets of immuno-oncology, including patient selection, management, and development of novel combinatorial approaches.

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