Abstract
OBJECTIVE: To investigate the clinical efficacy of alendronate sodium in patients with osteoporosis secondary to severe fractures. METHODS: A total of 102 patients with post-fracture osteoporosis were retrospectively included in this study. The control group (n=45) received standard treatment, while the research group (n=57) was additionally administered alendronate sodium. Bone metabolism markers, pain intensity (assessed by Visual Analogue Scale [VAS]), bone mineral density (BMD), and overall therapeutic efficacy were compared between the two groups. Multivariate logistic regression was performed to identify predictors of therapeutic efficacy. RESULTS: Compared with the control group, the research group demonstrated significantly greater improvements in bone metabolism markers, VAS scores, BMD, and overall efficacy. Univariate and multivariate logistic regression analyses further identified smoking history, alcohol abuse, and treatment modality as independent risk factors for treatment failure, while elevated serum bone Gla protein (BGP) levels were identified as a protective factor. CONCLUSION: Alendronate sodium significantly improves clinical outcomes in treating patients with osteoporosis secondary to severe fractures.