Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients

巨噬细胞促进免疫抑制患者放射治疗后循环肿瘤细胞介导的局部复发

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作者:Marjan Rafat, Todd A Aguilera, Marta Vilalta, Laura L Bronsart, Luis A Soto, Rie von Eyben, Meghana A Golla, Yasaman Ahrari, Stavros Melemenidis, Anosheh Afghahi, Melissa J Jenkins, Allison W Kurian, Kathleen C Horst, Amato J Giaccia, Edward E Graves

Significance

This study establishes the importance of macrophages in driving tumor cell recruitment to sites of local radiation therapy and suggests that this mechanism contributes to local recurrence in women with TNBC that are also immunosuppressed.Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/78/15/4241/F1.large.jpg Cancer Res; 78(15); 4241-52. ©2018 AACR.

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