Abstract
We report the complete genome sequence and predicted functional profile of Nocardia iowensis DSM 45197(T). N. iowensis DSM 45197(T) is a spore-forming, mesophilic, Gram-positive bacterium that was isolated from garden soil in Osceola, Iowa, USA. This organism has been exploited for its production of glycocinnamolyspermidine antibiotics and biotransformation of xenobiotic substances. Other significant features of N. iowensis DSM 45197(T) include the first fully characterized carboxylic acid reductase (CAR) and the first bacterial nitric oxide synthase system. The genome sequence of N. iowensis DSM 45197(T) can facilitate further understanding of its function, as well as the pathogenesis of Nocardia spp. N. iowensis DSM 45197(T) has a genome size of 8.95 Mbp; about 46% of the coding sequences have no known homologues and were labeled hypothetical proteins. This finding implies further potential for biomedical and biotechnological research applications.