Comparison of biological characteristics of mesenchymal stem cells derived from maternal-origin placenta and Wharton's jelly

母源胎盘与脐带胶间充质干细胞生物学特性比较

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作者:Gecai Chen, Aihuan Yue, Zhongbao Ruan, Yigang Yin, Ruzhu Wang, Yin Ren, Li Zhu

Conclusion

MSCs from both sources had similar basic biological properties, but decidual MSCs had slower proliferation and stronger immunosuppressive function.

Results

MSCs from Wharton's jelly and the decidua basalis exhibited similar morphology, immunophenotype, and differentiation potential to osteogenesis and adipogenesis. The percentage of MSCs in the G0/G1 phase was higher in the case of Wharton's jelly than in the case of the decidua basalis (P < 0.05). Decidual MSCs displayed more remarkable immunosuppressive effects on phytohemagglutinin-stimulated T-cell proliferation (P < 0.05).

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