Abstract
INTRODUCTION: Medical image segmentation is an important tool for doctors to accurately analyze the volume of brain tissue and lesions, which is important for the correct diagnosis of brain diseases. However, manual image segmentation methods are time-consuming, subjective and lack of repeatability, it needs to develop automatic and reliable methods for image segmentation. METHODS: Magnetic Resonance Imaging (MRI), a non-invasive imaging technique, is commonly used to detect, characterize and quantify tissues and lesions in the brain. Partial volume effect, gray scale in homogeneity, and lesions presents a great challenge for automatic medical image segmentation methods. So, the paper is dedicated to address the impact of partial volume effect and multiple sclerosis lesions on the segmentation accuracy in MRI. The objective function of the improved model and the post-processing method of lesion filling are researched based on the fuzzy clustering space and energy model. RESULTS: In particular, an energy-minimized segmentation algorithm is proposed. Through experimental verification, the AR-FCM algorithm can better overcome the problem of low segmentation accuracy of the RFCM algorithm for tissue boundary voxels and improve the segmentation accuracy of this algorithm. Meanwhile, a multi-channel input energy-minimization segmentation method with lesion filling and anatomical mapping is further proposed. DISCUSSION: The feasibility of the lesion filling strategy using post-processing can be confirmed and the segmentation accuracy is increased by comparison experiments.