Inflammatory Breast Cancer Promotes Development of M2 Tumor-Associated Macrophages and Cancer Mesenchymal Cells through a Complex Chemokine Network
炎性乳腺癌通过复杂的趋化因子网络促进 M2 肿瘤相关巨噬细胞和癌症间充质细胞的发展
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作者:Amanda Valeta-Magara, Abhilash Gadi, Viviana Volta, Beth Walters, Rezina Arju, Shah Giashuddin, Hua Zhong, Robert J Schneider
| 期刊: | Cancer Research | 影响因子: | 12.500 |
| 时间: | 2019 | 起止号: | 2019 Jul 1;79(13):3360-3371. |
| doi: | 10.1158/0008-5472.CAN-17-2158 | 研究方向: | 肿瘤 |
| 疾病类型: | 乳腺癌 | 细胞类型: | 巨噬细胞 |
Significance
This study uncovers a signaling network in which IBC cells commandeer macrophages to become tumor-promoting, and they in turn drive IBC cells to be more cancer stem-like, mesenchymal, and aggressive.Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/79/13/3360/F1.large.jpg.
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