Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases

对患者转移瘤细胞外基质成分的蛋白质组学分析确定了持续升高的蛋白质,可用于开发针对原发性肿瘤和转移瘤的纳米抗体

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作者:Noor Jailkhani, Karl R Clauser, Howard H Mak, Steffen Rickelt, Chenxi Tian, Charles A Whittaker, Kenneth K Tanabe, Stephen R Purdy, Steven A Carr, Richard O Hynes

Significance

Nanobodies specific for extracellular matrix markers commonly expressed in primary tumors and metastases are promising agents for noninvasive detection of tumors and metastases and potential tools for targeted therapy.

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