Abstract
A fitness landscape is a mapping from a space of discrete genotypes to the real numbers. A path in a fitness landscape is a sequence of genotypes connected by single mutational steps. Such a path is said to be accessible if the fitness values of the genotypes encountered along the path increase monotonically. We study accessible paths on random fitness landscapes of the House-of-Cards type, on which fitness values are independent, identically and continuously distributed random variables. The genotype space is taken to be a Cartesian power graph [Formula: see text], where [Formula: see text] is the number of genetic loci and the allele graph [Formula: see text] encodes the possible allelic states and mutational transitions on one locus. The probability of existence of accessible paths between two genotypes at a distance linear in [Formula: see text] displays a transition from 0 to a positive value at a threshold [Formula: see text] for the fitness difference between the initial and final genotype. We derive a lower bound on [Formula: see text] for general [Formula: see text] and show that this bound is tight for a large class of allele graphs. Our results generalize previous results for accessibility percolation on the biallelic hypercube, and compare favorably to published numerical results for multiallelic Hamming graphs.