Background
Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of inherited renal failure that
Significance
Placental abnormalities contribute to the fetal demise of Pkd(-/-) embryos. Endothelial cell specific deletion of Pkd1 or Pkd2 recapitulates a subset of findings seen in Pkd null animals. Our studies reveal a complex role for polycystins in maintaining vascular integrity.