BeadNet: deep learning-based bead detection and counting in low-resolution microscopy images

BeadNet:基于深度学习的低分辨率显微图像微珠检测与计数

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Abstract

MOTIVATION: An automated counting of beads is required for many high-throughput experiments such as studying mimicked bacterial invasion processes. However, state-of-the-art algorithms under- or overestimate the number of beads in low-resolution images. In addition, expert knowledge is needed to adjust parameters. RESULTS: In combination with our image labeling tool, BeadNet enables biologists to easily annotate and process their data reducing the expertise required in many existing image analysis pipelines. BeadNet outperforms state-of-the-art-algorithms in terms of missing, added and total amount of beads. AVAILABILITY AND IMPLEMENTATION: BeadNet (software, code and dataset) is available at https://bitbucket.org/t_scherr/beadnet. The image labeling tool is available at https://bitbucket.org/abartschat/imagelabelingtool. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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