Abstract
Beta thalassemia major is a hereditary hematological disorder characterized by ineffective erythropoiesis, leading to chronic hemolytic anemia and iron overload due to frequent blood transfusions. Liver complications, including chronic liver disease, are common in thalassemia major patients, primarily attributed to iron overload. This prospective cross-sectional study aims to assess the role of transient elastography (TE) in evaluating chronic liver disease and its correlation with serum ferritin levels and liver function tests in beta thalassemia major patients. A total of 110 patients diagnosed with beta thalassemia major were recruited from the Department of General Medicine & Hematology, SCB Medical College and Hospital for this study. TE was performed to measure liver stiffness, and serum ferritin levels along with liver function tests were evaluated. Results were analyzed statistically to assess the relationship between liver stiffness measurements (LSM) and serum ferritin levels. There was a significant correlation between liver stiffness measured by TE and serum ferritin groups (p < 0.05, Kruskal Wallis H test), indicating a strong association between iron overload and chronic liver disease in beta thalassemia major patients. The findings suggest that transient elastography could be a valuable tool in detecting chronic liver disease in beta thalassemia major patients, with LSM showing a positive correlation with serum ferritin levels.