Abstract
Gastrointestinal stromal tumors, previously referred to as leiomyomas and leiomyosarcomas, are one of the most common mesenchymal tumors of the gastrointestinal tract, predominantly located in the stomach (60%-70%), followed by the small intestine (20%-30%). They manifest at any age but more commonly in patients older than 50 years. Patients with gastrointestinal stromal tumors usually have vague and nonspecific symptoms. The diagnosis is sometimes challenging requiring multiple imaging modalities, including computed tomography and magnetic resonance imaging, used for diagnosis, staging, and surveillance. Treatment involves surgery and targeted therapy. Serious complications have been reported such as intussusception which is exceptionally rare due to the extraluminal growth pattern tendency of gastrointestinal stromal tumors. We present the case of a 77-year-old female with duodeno-duodenal intussusception secondary to a gastrointestinal stromal tumor. This case report contributes valuable insight into the diverse presentation and complications of gastrointestinal stromal tumors.