Abstract
The current systematic review aims to check the impact of gender-affirming interventions (GAIs) on the mental health and body satisfaction of transgender individuals. The literature search was carried out in PubMed, ProQuest, and Scopus, and screening was done based on PRISMA guidelines. Data were extracted using a custom-developed template, and quality assessment was carried out using ROBINS-I and ROB-2. Sixteen studies were finalised for the review. Data were synthesised narratively based on the impact of these GAIs on anxiety, depression, self-harm, and body image satisfaction. Individuals who received the GAIs showed significant improvement in their mental health and body image acceptance. A system of integrative medical, surgical, and psychological interventions for transgender healthcare by incorporating the clinicians, researchers, and policymakers relied on comprehensive evidence on the diverse experiences of transgender individuals. The long-term effects of GAIs remain unclear, underscoring the need for further longitudinal research.