Abstract
Amebiasis, caused by Entamoeba histolytica, can present diagnostic challenges due to its diverse clinical manifestations and potential for misdiagnosis, particularly in regions with low incidence rates. We report a case of a 9-year-old girl initially diagnosed with inflammatory bowel disease but later confirmed to have amebic colitis. Prompt recognition and treatment with metronidazole led to symptom resolution. This case underscores the importance of considering amebiasis in the differential diagnosis, emphasizing the need for vigilance and thorough history and clinical evaluation to enable early diagnosis and treatment. Improved diagnostic modalities are needed to enhance accuracy and optimize treatment outcomes.