Abstract
Serpentine channels coupling inertial and secondary flows enable effective particle focusing and separation, showing great potential in clinical diagnostics and drug screening. However, the nonsteady secondary flows in the serpentine channel make the evolution of inertial migration unclear, hindering the development and application of the serpentine channel. Herein, to refine the inertial migration mechanism, we established a model with varying curvature ratios to study the effect of secondary flow on particle migration in the serpentine channel. This method used direct numerical simulation (DNS) to calculate inertial lift, mapped the inertial lift to cross sections of the serpentine channel, and deciphered the inertial migration by using the Lagrangian particle tracking (LPT) method. The inertial migration of microparticles is experimentally investigated to validate the established numerical model. The results indicate that particle migration in serpentine channels follows a two-stage migration. An increase in secondary flow accelerates the second stage of the migration process while slowing the first stage process. Subsequently, we investigated the effects of different parameters, including Reynolds number, aspect ratio, and blockage ratio, on the equilibrium positions of particles, providing guidelines for the high-resolution separation of particles. Taking flow resistance into account, the dimensionless study makes the separation of arbitrary-sized particles possible. This work reveals the migration mechanism in serpentine channels, paving the way for the inertial separation of the particles.