Background
Graves' disease (GD) is a complex disease in which genetic predisposition is modified by environmental factors. The
Conclusions
HLADRB1*03 allele is associated with young age at diagnosis of Graves' disease in Polish population.
Methods
735 GD patients and 1216 healthy controls from Poland were included into the study. Eight genetic variants in the HLA-DRB1, TNF, CTLA4, CD40, NFKb, PTPN22, IL4 and IL10 genes were genotyped. Patients were stratified by the age at diagnosis of GD and the association with genotype was analysed.
Results
Polymorphism in the HLA-DRB1, TNF and CTLA4 genes were associated with GD. The carriers of the HLA DRB1*03 allele were more frequent in patients with age at GD diagnosis ≤30 years than in patients with older age at GD diagnosis. Conclusions: HLADRB1*03 allele is associated with young age at diagnosis of Graves' disease in Polish population.