Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin, a major red wine polyphenol

红葡萄酒中的主要多酚——锦葵花色素在 RAW264.7 巨噬细胞中的抗氧化和抗炎作用

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作者:Eszter Bognar, Zsolt Sarszegi, Aliz Szabo, Balazs Debreceni, Nikoletta Kalman, Zsuzsanna Tucsek, Balazs Sumegi, Ferenc Gallyas Jr

Background

Red wine polyphenols can prevent cardiovascular and inflammatory diseases. Resveratrol, the most extensively studied constituent, is unlikely to solely account for these beneficial effects because of its rather low abundance and bioavailability. Malvidin is far the most abundant polyphenol in red wine; however, very limited data are available about its effect on inflammatory processes and kinase signaling pathways.

Conclusions

These effects of malvidin may explain the previous findings and at least partially account for the positive effects of moderate red wine consumption on inflammation-mediated chronic maladies such as obesity, diabetes, hypertension and cardiovascular disease.

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