Generation of human induced pluripotent stem cell line from Alzheimer's disease patient with PSEN2 N141I mutation using integration-free non-viral method
使用无整合非病毒方法从患有 PSEN2 N141I 突变的阿尔茨海默病患者中生成人类诱导性多能干细胞系
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作者：Harry Murti, Kelvin Pieknell, Indra Bachtiar, Yanuar Alan Sulistio, Sang-Hun Lee
| 期刊： | Stem Cell Research | 影响因子： | 0.800 |
| 时间： | 2020 | 起止号： | 2020 Jun 29:47:101892. |
| doi： | 10.1016/j.scr.2020.101892 | 种属： | Human |
| 研究方向： | 发育与干细胞、微生物学、神经 | 疾病类型： | 阿尔茨海默症 |
| 细胞类型： | 干细胞 | |
Abstract
Induced pluripotent stem cell (iPSC) line HUi001-A was reprogrammed from skin fibroblasts via non-integrating, virus free self-replicating RNA. Skin fibroblasts from an 81-year-old female Caucasian familial Alzheimer's disease patient of Volga German family carrying N141I mutation in the PSEN2 gene (familial AD4, clinical summary confirmed Alzheimer's disease) was obtained from the Coriell Institute (AG09908). Generated iPSCs were characterized and pluripotency was confirmed.
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