Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase
组蛋白乙酰转移酶的强效抑制剂山竹酚体外扩增人类造血干细胞
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作者:Taito Nishino, Changshan Wang, Makiko Mochizuki-Kashio, Mitsujiro Osawa, Hiromitsu Nakauchi, Atsushi Iwama
| 期刊: | PLoS One | 影响因子: | 2.900 |
| 时间: | 2011 | 起止号: | 2011;6(9):e24298. |
| doi: | 10.1371/journal.pone.0024298 | 研究方向: | 发育与干细胞 |
| 细胞类型: | 干细胞 | |
Background
Human cord blood (hCB) is the main source of hematopoietic stem and progenitor cells (HSCs/PCs) for transplantation. Efforts to overcome relative shortages of HSCs/PCs have led to technologies to expand HSCs/PCs ex vivo. However,
Significance
Our findings identify Garcinol as the first natural product acting on HSCs/PCs and suggest the inhibition of HAT to be an alternative approach for manipulating HSCs/PCs.
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