Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase

组蛋白乙酰转移酶的强效抑制剂山竹酚体外扩增人类造血干细胞

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作者:Taito Nishino, Changshan Wang, Makiko Mochizuki-Kashio, Mitsujiro Osawa, Hiromitsu Nakauchi, Atsushi Iwama

Background

Human cord blood (hCB) is the main source of hematopoietic stem and progenitor cells (HSCs/PCs) for transplantation. Efforts to overcome relative shortages of HSCs/PCs have led to technologies to expand HSCs/PCs ex vivo. However,

Significance

Our findings identify Garcinol as the first natural product acting on HSCs/PCs and suggest the inhibition of HAT to be an alternative approach for manipulating HSCs/PCs.

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