Facile fabrication of polyanhydride/anesthetic nanoparticles with tunable release kinetics

简便制备具有可调释放动力学的聚酐/麻醉纳米粒子

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作者:Bret D Ulery, Ho-Man Kan, Bryce A Williams, Balaji Narasimhan, Kevin W-H Lo, Lakshmi S Nair, Cato T Laurencin

Abstract

This work illustrates a two-step strategy for the fabrication of polymer/drug nanoparticles. Utilizing solvent/non-solvent precipitation and gaseous basification, composite nanoparticles with 0-100% drug loadings are fabricated. Drug release kinetics are dictated by nanoparticle composition allowing future tuning for therapeutic applications.

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