An osteoblast-derived proteinase controls tumor cell survival via TGF-beta activation in the bone microenvironment
成骨细胞衍生的蛋白酶通过骨微环境中的 TGF-β 激活来控制肿瘤细胞存活
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作者：Sophie Thiolloy, James R Edwards, Barbara Fingleton, Daniel B Rifkin, Lynn M Matrisian, Conor C Lynch
| 期刊： | PLoS One | 影响因子： | 2.900 |
| 时间： | 2012 | 起止号： | 2012;7(1):e29862. |
| doi： | 10.1371/journal.pone.0029862 | 研究方向： | 肿瘤 |
| 细胞类型： | 肿瘤细胞 | 信号通路： | TGF-β |
Background
Breast to bone metastases frequently induce a "vicious cycle" in which osteoclast mediated bone resorption and proteolysis
Significance
Collectively, these studies identify a novel "mini-vicious cycle" between the osteoblast and metastatic cancer cells that is key for initial tumor survival in the bone microenvironment. In conclusion, the findings of our study suggest that the targeted inhibition of MMP-2 and/or TGFβ would be beneficial for the treatment of bone metastases.
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