Cross-sectional analysis of dyslipidemia risk in coal mine workers: from epidemiology to animal models

煤矿工人血脂异常风险的横断面分析:从流行病学到动物模型

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作者:Hui Zhao #, Huihui Tao #, Jifeng Fu, Weilong Hou, Chunxiao Hu, Yafeng Liu, Xuansheng Ding, Dong Hu, Yong Dai

Methods

We selected a population who underwent occupational health examinations at Huainan Yangguang Xinkang Hospital from March 2020 to July 2022. Participants were divided into two groups based on the presence or absence of dyslipidemia, and their baseline information was collected, including records of coal dust exposure. We employed single-factor analysis to identify risk factors for dyslipidemia and adjusted for confounding factors in the adjusted models. Additionally, we explored the effects in different populations using stratified analysis, smooth curve fitting, and propensity score matching. Finally, we confirmed the causal relationship between coal dust exposure and dyslipidemia by examining tissue sections and lipid-related indicators in a mouse model of coal dust exposure.

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