PARP Inhibitors Differentially Regulate Immune Responses in Distinct Genetic Backgrounds of High-Grade Serous Tubo-Ovarian Carcinoma
PARP 抑制剂对高级别浆液性输卵管卵巢癌不同遗传背景下的免疫反应进行差异调节
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作者:Luiza Doro Pereira #, Monica Wielgos-Bonvallet #, Selim Misirlioglu, Alireza Khodadai-Jamayran, Petar Jelinic, Douglas A Levine
Abstract
This work highlights how different PARPis, especially talazoparib, modulate immune-related gene expression in ovarian cancer cells, independent of the cGAS-STING pathway. These findings may improve our understanding of how different PARPis affect the immune system in various genetic backgrounds.
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