Production of dendritic cell vaccines using different methods with equivalent results: Implications for emerging centers

使用不同方法生产树突状细胞疫苗并获得同等结果:对新兴中心的启示

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作者:Adriana da Silva Santos Duarte, Audrey Basso Zangirolami, Irene Santos, Fernanda Soares Niemann, Helen Naemi Honma, Emerson Clayton Amaro, Maurício Wesley Perroud Jr, Fernando Vieira Pericole, Simone Cristina Olenscki Gilli, Bruno Deltreggia Benites, Sara Teresinha Olalla Saad

Conclusion

These findings may have important implications for emerging centers interested in using this medical approach and potentially increase the access of a greater number of patients to this therapeutic option.

Results

The results demonstrate the equivalence of the 3 methods in relation to the yield and final quality of the product, however with considerable differences between the costs of these procedures. In addition, this study also demonstrates the feasibility of the antigenic pulse with autologous tumor cell lysates, constituting a source of antigens, not only easily obtained and manipulated, but also specific to the patient's tumor.

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