Time and dose-dependent effects of Labisia pumila on bone oxidative status of postmenopausal osteoporosis rat model

拉比西亚对绝经后骨质疏松大鼠骨氧化状态的时间和剂量依赖性影响

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作者:Nadia Mohd Effendy, Ahmad Nazrun Shuid

Results

The SOD levels of the sham-operated and all the treatment groups were significantly higher than the OVX groups at all treatment periods. The GPx level of ERT and LP100 groups at the 9th week of treatment were significantly higher than the baseline and OVX groups. MDA level of the OVX group was significantly higher than all the other groups at weeks 6 and 9. The LP20 and LP100 groups at the 9th week of treatment had significantly lower MDA levels than the ERT group. There were no significant differences between LP20 and LP100 for all parameters. Thus, LP supplementations at both doses, which showed the best results at 9 weeks, may reduce oxidative stress which in turn may prevent bone loss via its anti-oxidative property.

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