Interferon-α/β and anti-fibroblast growth factor receptor 1 monoclonal antibody suppress hepatic cancer cells in vitro and in vivo

干扰素-α/β和抗成纤维细胞生长因子受体1单克隆抗体在体内外抑制肝癌细胞

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作者:Shigeru Sasaki, Tadao Ishida, Minoru Toyota, Akinobu Ota, Hiromu Suzuki, Akinori Takaoka, Hiroshi Yasui, Hiroyuki Yamamoto, Hideyasu Takagi, Masahiro Maeda, Tsutomu Seito, Masayuki Tsujisaki, Yasuhisa Shinomura, Kohzoh Imai

Background

Hepatocellular carcinoma (HCC) is the most commonly occurring primary liver cancer and ranks as the fifth most frequently occurring cancer, overall, and the third leading cause of cancer deaths, worldwide. At present, effective therapeutic options available for HCC are limited; consequently, the prognosis for these patients is poor. Our

Conclusions

Our results suggest that the combined use of an anti-FGFR1 antibody and interferon-α/β is a promising approach to the treatment of HCC.

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