In vitro activities of miltefosine and two novel antifungal biscationic salts against a panel of 77 dermatophytes

米替福新和两种新型抗真菌双阳离子盐对 77 种皮肤癣菌的体外活性

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作者:Zhongsheng Tong, Fred Widmer, Tania C Sorrell, Zofia Guse, Katrina A Jolliffe, Catriona Halliday, Ok Cha Lee, Fanrong Kong, Lesley C Wright, Sharon C A Chen

Abstract

The susceptibilities of 77 dermatophytes to miltefosine (MI), 1,12-bis(4-pentylpyridinium)dodecane (PYR), 1,12-bis(tributylammonium)dodecane (AM), itraconazole (ITC), terbinafine (TRB), and butenafine (BTF) were compared. Geometric mean MICs of TRB, BTF, ITC, MI, PYR, and AM were 0.039, 0.059, 1.718, 0.671, 6.006, and 4.771 microg/ml, respectively. MI was more active than ITC (P < 0.001).

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