Non-invasive molecular imaging of fibrosis using a collagen-targeted peptidomimetic of the platelet collagen receptor glycoprotein VI

使用胶原靶向的血小板胶原受体糖蛋白 VI 肽模拟物进行纤维化的非侵入性分子成像

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作者:Julien Muzard, Laure Sarda-Mantel, Stéphane Loyau, Alain Meulemans, Liliane Louedec, Claudie Bantsimba-Malanda, Florence Hervatin, Joëlle Marchal-Somme, Jean Baptiste Michel, Dominique Le Guludec, Philippe Billiald, Martine Jandrot-Perrus

Background

Fibrosis, which is characterized by the pathological accumulation of collagen, is recognized as an important feature of many chronic diseases, and as such, constitutes an enormous health burden. We need non-invasive specific

Significance

Collagelin is a new collagen-targeting agent which may be useful for non-invasive detection of fibrosis in a broad spectrum of diseases.

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