1-Methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in rhesus macaque

1-甲基-4-苯基吡啶立体定向输注完全且特异性地消融了恒河猴的黑质纹状体多巴胺能通路

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作者:Xiaoguang Lei, Hao Li, Baihui Huang, Joshua Rizak, Ling Li, Liqi Xu, Tianzhuang Huang, Li Liu, Jing Wu, Longbao Lü, Zhengbo Wang, Yingzhou Hu, Weidong Le, Xingli Deng, Jiali Li, Yonggang Yao, Lin Xu, Xintian Hu, Baorong Zhang

Conclusion

Taken together, in addition to providing a specific nigrostriatal DA lesioned model, this method, combined with brain stimulation or other techniques, can be applied as a powerful tool for the complete lesion of any desired DA pathway in order to study its specific functions in the brain.

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