日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism

利用人性化药物代谢模型加速传染病药物的发现和开发

A Kenneth MacLeod, Kevin-Sebastien Coquelin, Leticia Huertas, Frederick R C Simeons, Jennifer Riley, Patricia Casado, Laura Guijarro, Ruth Casanueva, Laura Frame, Erika G Pinto, Liam Ferguson, Christina Duncan, Nicole Mutter, Yoko Shishikura, Colin J Henderson, David Cebrian, C Roland Wolf, Kevin D

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

醛酮还原酶是 NRF2 活性的生物标志物,在非小细胞肺癌中协同过度表达

A Kenneth MacLeod, Lourdes Acosta-Jimenez, Philip J Coates, Michael McMahon, Frank A Carey, Tadashi Honda, Colin J Henderson, C Roland Wolf

Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models

孕烷 X 受体的激活状态影响人源化小鼠模型中维莫非尼的可用性

A Kenneth MacLeod, Lesley A McLaughlin, Colin J Henderson, C Roland Wolf

An enhanced in vivo stable isotope labeling by amino acids in cell culture (SILAC) model for quantification of drug metabolism enzymes

增强体内稳定同位素标记细胞培养氨基酸 (SILAC) 模型用于量化药物代谢酶

A Kenneth MacLeod, Padraic G Fallon, Sheila Sharp, Colin J Henderson, C Roland Wolf, Jeffrey T-J Huang

A targeted in vivo SILAC approach for quantification of drug metabolism enzymes: regulation by the constitutive androstane receptor

靶向体内 SILAC 方法定量药物代谢酶:由组成型雄烷受体调控

A Kenneth Macleod, Tuo Zang, Zoe Riches, Colin J Henderson, C Roland Wolf, Jeffrey T-J Huang