The UDP-glucuronosyltransferase (UGT) 1A polymorphism c.2042C>G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure
UDP-葡萄糖醛酸转移酶 (UGT) 1A 多态性 c.2042C>G (rs8330) 与人类肝脏对乙酰氨基酚葡萄糖醛酸化增加、UGT1A 外显子 5a/5b 剪接变体 mRNA 比率增加以及意外对乙酰氨基酚诱发的急性肝衰竭风险降低有关
期刊:Journal of Pharmacology and Experimental Therapeutics
影响因子:3.1
doi:10.1124/jpet.112.202010
Michael H Court, Marina Freytsis, Xueding Wang, Inga Peter, Chantal Guillemette, Suwagmani Hazarika, Su X Duan, David J Greenblatt, William M Lee; Acute Liver Failure Study Group
