日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting CDK12 disrupts estrogen-receptor chromatin recruitment and ER-MED1 transcription in advanced ER+ breast cancer

靶向 CDK12 会破坏晚期 ER+ 乳腺癌中雌激素受体染色质募集和 ER-MED1 转录

Ottaviani, Daniela; Ola, Mihaela; Allotta, Alessandra; Maati Chaibi, Yasmine; Hickey, Seán; Jagust, Petra; Cosgrove, Nicola; Cocchiglia, Sinéad; Bane, Fiona; Fallon, Ramón; Daly, Gordon; Hegarty, Aisling; Hudson, Lance; Sheehan, Katherine; Kalsi, Shannon; Shovlin, Stephen; Powell, Aoibhín; Bahl, Ash; Ainscow, Ed; Oesterreich, Steffi; Lee, Adrian V; Couch, Fergus J; Hill, Arnold D K; Varešlija, Damir; Young, Leonie

Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors

综合 CRISPR 筛选和药物分析可确定 EGFR、ALK 和 BRAF/MEK 抑制剂的联合用药机会

Ralph Tiedt, Frederick J King, Christelle Stamm, Matthew J Niederst, Scott Delach, Sabine Zumstein-Mecker, Jodi Meltzer, Iain J Mulford, Emma Labrot, Barbara Schacher Engstler, Sabrina Baltschukat, Grainne Kerr, Javad Golji, Daniel Wyss, Christian Schnell, Edward Ainscow, Jeffrey A Engelman, William

The CDK7 inhibitor CT7001 (Samuraciclib) targets proliferation pathways to inhibit advanced prostate cancer

CDK7 抑制剂 CT7001 (Samuraciclib) 靶向增殖途径以抑制晚期前列腺癌

Theodora A Constantin, Anabel Varela-Carver, Kyle K Greenland, Gilberto Serrano de Almeida, Ellen Olden, Lucy Penfold, Simon Ang, Alice Ormrod, Damien A Leach, Chun-Fui Lai, Edward K Ainscow, Ash K Bahl, David Carling, Matthew J Fuchter, Simak Ali, Charlotte L Bevan

A Phase I Trial of CT900, a Novel α-Folate Receptor-Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer

CT900(一种新型α-叶酸受体介导的胸苷酸合成酶抑制剂)在实体瘤患者中的I期临床试验,并纳入高级别浆液性卵巢癌患者作为扩展队列。

Banerjee, Susana; Michalarea, Vasiliki; Ang, Joo Ern; Ingles Garces, Alvaro; Biondo, Andrea; Funingana, Ionut-Gabriel; Little, Martin; Ruddle, Ruth; Raynaud, Florence; Riisnaes, Ruth; Gurel, Bora; Chua, Sue; Tunariu, Nina; Porter, Joanna C; Prout, Toby; Parmar, Mona; Zachariou, Anna; Turner, Alison; Jenkins, Ben; McIntosh, Stuart; Ainscow, Ed; Minchom, Anna; Lopez, Juanita; de Bono, Johann; Jones, Robert; Hall, Emma; Cook, Natalie; Basu, Bristi; Banerji, Udai

Structure-guided combination therapy to potently improve the function of mutant CFTRs

结构引导联合疗法有效改善突变 CFTR 的功能

Guido Veit, Haijin Xu, Elise Dreano, Radu G Avramescu, Miklos Bagdany, Lenore K Beitel, Ariel Roldan, Mark A Hancock, Cecilia Lay, Wei Li, Katelin Morin, Sandra Gao, Puiying A Mak, Edward Ainscow, Anthony P Orth, Peter McNamara, Aleksander Edelman, Saul Frenkiel, Elias Matouk, Isabelle Sermet-Gaudel

A Fully Automated High-Throughput Flow Cytometry Screening System Enabling Phenotypic Drug Discovery

全自动高通量流式细胞术筛选系统助力表型药物发现

John Joslin ,James Gilligan ,Paul Anderson ,Catherine Garcia ,Orzala Sharif ,Janice Hampton ,Steven Cohen ,Miranda King ,Bin Zhou ,Shumei Jiang ,Christopher Trussell ,Robert Dunn ,John W Fathman ,Jennifer L Snead ,Anthony E Boitano ,Tommy Nguyen ,Michael Conner ,Mike Cooke ,Jennifer Harris ,Ed Ainscow ,Yingyao Zhou ,Chris Shaw ,Dan Sipes ,James Mainquist ,Scott Lesley

Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma

ALK 和 CDK4/6 双重抑制显示出对抗神经母细胞瘤的协同作用

Andrew C Wood, Kateryna Krytska, Hannah T Ryles, Nicole R Infarinato, Renata Sano, Theodore D Hansel, Lori S Hart, Frederick J King, Timothy R Smith, Edward Ainscow, Kathryn B Grandinetti, Tove Tuntland, Sunkyu Kim, Giordano Caponigro, You Qun He, Shiva Krupa, Nanxin Li, Jennifer L Harris, Yaël P Mo

Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

线粒体复合物 I 位点 IQ 处超氧化物 H2O2 生成的抑制剂可防止干细胞增生和缺血再灌注损伤

Martin D Brand, Renata L S Goncalves, Adam L Orr, Leonardo Vargas, Akos A Gerencser, Martin Borch Jensen, Yves T Wang, Simon Melov, Carolina N Turk, Jason T Matzen, Victoria J Dardov, H Michael Petrassi, Shelly L Meeusen, Irina V Perevoshchikova, Heinrich Jasper, Paul S Brookes, Edward K Ainscow

Anterior Cervical Discectomy and Fusion with Stand-Alone Trabecular Metal Cages as a Surgical Treatment for Cervical Radiculopathy: Mid-Term Outcomes

采用独立式小梁金属笼进行前路颈椎间盘切除融合术治疗颈椎神经根病:中期疗效

ElAbed, Khaldoun; Shawky, Ahmad; Barakat, Mo; Ainscow, Donald

Suppressors of superoxide production from mitochondrial complex III

线粒体复合物 III 超氧化物生成抑制剂

Adam L Orr, Leonardo Vargas, Carolina N Turk, Janine E Baaten, Jason T Matzen, Victoria J Dardov, Stephen J Attle, Jing Li, Douglas C Quackenbush, Renata L S Goncalves, Irina V Perevoshchikova, H Michael Petrassi, Shelly L Meeusen, Edward K Ainscow, Martin D Brand