日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Probing the correlation between ligand efficacy and conformational diversity at the α1A-adrenoreceptor reveals allosteric coupling of its microswitches

探究 α1A 肾上腺素受体的配体功效与构象多样性之间的相关性,揭示其微开关的变构耦合

Feng-Jie Wu, Lisa M Williams, Alaa Abdul-Ridha, Avanka Gunatilaka, Tasneem M Vaid, Martina Kocan, Alice R Whitehead, Michael D W Griffin, Ross A D Bathgate, Daniel J Scott, Paul R Gooley

Diazepam is not a direct allosteric modulator of α1-adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase-4

地西泮不是 α1-肾上腺素能受体的直接变构调节剂,而是通过抑制磷酸二酯酶-4 来调节受体信号传导

Lisa M Williams, Xiaoji He, Tasneem M Vaid, Alaa Abdul-Ridha, Alice R Whitehead, Paul R Gooley, Ross A D Bathgate, Spencer J Williams, Daniel J Scott