日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Antisense oligonucleotides directed against App and Rab5 normalized endosomal Rab activity and reversed DS-AD-linked degenerative phenotypes in the Dp16 mouse model of Down syndrome.

针对 App 和 Rab5Â 的反义寡核苷酸可使内体 Rab 活性正常化,并逆转唐氏综合征 Dp16 小鼠模型中与 DS-AD 相关的退行性表型

Chen Xu-Qiao, Zuo Xinxin, Becker Ann, Mante Michael, Florio Jazmin B, Jadhav Satish G, Albay Ricardo, Johnstone Aaron, Karachentsev Dmitry, Rissman Robert, Zhao Hien, Dowdy Steven F, Mobley William C

γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome.

γ-分泌酶调节剂 BPN15606 降低了 Aβ42 和 Aβ40,并对抗了唐氏综合征小鼠模型中的阿尔茨海默病相关病理

Chen Xu-Qiao, Becker Ann, Albay Ricardo, Nguyen Phuong D, Karachentsev Dmitry, Roberts Amanda J, Rynearson Kevin D, Tanzi Rudolph E, Mobley William C

Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes

有效的抗阿尔茨海默病Aβ疗法涉及清除特定的Aβ寡聚体亚型。

Knight, Elysse M; Kim, Soong Ho; Kottwitz, Jessica C; Hatami, Asa; Albay, Ricardo; Suzuki, Akinobu; Lublin, Alex; Alberini, Cristina M; Klein, William L; Szabo, Paul; Relkin, Norman R; Ehrlich, Michelle; Glabe, Charles G; Gandy, Sam; Steele, John W

Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers

构象依赖性单克隆抗体可区分前纤维状Aβ寡聚体的不同复制株或构象体。

Kayed, Rakez; Canto, Isabel; Breydo, Leonid; Rasool, Suhail; Lukacsovich, Tamas; Wu, Jessica; Albay, Ricardo 3rd; Pensalfini, Anna; Yeung, Stephen; Head, Elizabeth; Marsh, J Lawrence; Glabe, Charles