日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A pharmacokinetic-pharmacodynamic model for the MET tyrosine kinase inhibitor, savolitinib, to explore target inhibition requirements for anti-tumour activity

MET 酪氨酸激酶抑制剂沃利替尼的药代动力学-药效学模型,用于探索抗肿瘤活性的靶标抑制要求

Rhys D O Jones, Mike Grondine, Alexandra Borodovsky, Maryann San Martin, Michelle DuPont, Celina D'Cruz, Alwin Schuller, Ryan Henry, Evan Barry, Lillian Castriotta, Rana Anjum, Klas Petersson, Tarjinder Sahota, Ghada F Ahmed

Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity

小分子AZD4635作为A2AR信号通路抑制剂,可恢复包括CD103+树突状细胞在内的免疫细胞功能,从而增强抗肿瘤免疫力。

Alexandra Borodovsky # ,Christine M Barbon # ,Yanjun Wang ,Minwei Ye ,Laura Prickett ,Dinesh Chandra ,Joseph Shaw ,Nanhua Deng ,Kris Sachsenmeier ,James D Clarke ,Bolan Linghu ,Giles A Brown ,James Brown ,Miles Congreve ,Robert Ky Cheng ,Andrew S Dore ,Edward Hurrell ,Wenlin Shao ,Richard Woessner ,Corinne Reimer ,Lisa Drew ,Stephen Fawell ,Alwin G Schuller ,Deanna A Mele

Demethylation and epigenetic modification with 5-azacytidine reduces IDH1 mutant glioma growth in combination with temozolomide

5-氮杂胞苷去甲基化和表观遗传修饰与替莫唑胺联合使用可降低 IDH1 突变型胶质瘤的生长

Alex Shimura Yamashita, Marina da Costa Rosa, Alexandra Borodovsky, William T Festuccia, Timothy Chan, Gregory J Riggins

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

使用 procaspase-3 激活剂和替莫唑胺进行协同靶向治疗可延长神经胶质瘤啮齿动物模型的生存期,并且可用于治疗犬恶性神经胶质瘤患者

Avadhut D Joshi #, Rachel C Botham #, Lisa J Schlein, Howard S Roth, Antonella Mangraviti, Alexandra Borodovsky, Betty Tyler, Steve Joslyn, Jayme S Looper, Michael Podell, Timothy M Fan, Paul J Hergenrother, Gregory J Riggins

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine

DNMT 抑制剂地西他滨可有效诱导 IDH1 突变型胶质瘤细胞分化并抑制其生长

Sevin Turcan, Armida W M Fabius, Alexandra Borodovsky, Alicia Pedraza, Cameron Brennan, Jason Huse, Agnes Viale, Gregory J Riggins, Timothy A Chan