日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lymphoid gene expression supports neuroprotective microglia function

淋巴样基因表达支持神经保护性小胶质细胞功能

Pinar Ayata # ,Jessica M Crowley # ,Matthew F Challman # ,Vinaya Sahasrabuddhe ,Maud Gratuze ,Sebastian Werneburg ,Diogo Ribeiro ,Emma C Hays ,Violeta Durán-Laforet ,Travis E Faust ,Philip Hwang ,Francisco Mendes Lopes ,Chrysa Nikopoulou ,Sarah Buchholz ,Robert E Murphy ,Taoyu Mei ,Anna A Pimenova ,Carmen Romero-Molina ,Francesca Garretti ,Tulsi A Patel ,Claudia De Sanctis ,Angie V Ramirez Jimenez ,Megan Crow ,Felix D Weiss ,Jason D Ulrich ,Edoardo Marcora ,John W Murray ,Felix Meissner ,Andreas Beyer ,Dan Hasson ,John F Crary ,Dorothy P Schafer ,David M Holtzman ,Alison M Goate ,Alexander Tarakhovsky ,Anne Schaefer

A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation

一种将 HDAC/MECP2 复合物募集到 PU.1 基序的新型分子类可减少神经炎症

William T Ralvenius, Alison E Mungenast, Hannah Woolf, Margaret M Huston, Tyler Z Gillingham, Stephen K Godin, Jay Penney, Hugh P Cam, Fan Gao, Celia G Fernandez, Barbara Czako, Yaima Lightfoot, William J Ray, Adrian Beckmann, Alison M Goate, Edoardo Marcora, Carmen Romero-Molina, Pinar Ayata, Anne

Genome-Wide Association Study of Cardiovascular Resilience Identifies Protective Variation in the CETP Gene

心血管恢复力的全基因组关联研究确定了 CETP 基因的保护性变异

Chenglong Yu, Andrew Bakshi, Gerald F Watts, Alan E Renton, Brian Fulton-Howard, Alison M Goate, Pradeep Natarajan, Daniel I Chasman, Liubov Robman, Robyn L Woods, Robyn Guymer, Rory Wolfe, Le Thi Phuong Thao, John J McNeil, Andrew M Tonkin, Stephen J Nicholls, Paul Lacaze

Cholesterol and matrisome pathways dysregulated in astrocytes and microglia

星形胶质细胞和小胶质细胞中胆固醇和基质组通路失调

Julia Tcw ,Lu Qian ,Nina H Pipalia ,Michael J Chao ,Shuang A Liang ,Yang Shi ,Bharat R Jain ,Sarah E Bertelsen ,Manav Kapoor ,Edoardo Marcora ,Elizabeth Sikora ,Elizabeth J Andrews ,Alessandra C Martini ,Celeste M Karch ,Elizabeth Head ,David M Holtzman ,Bin Zhang ,Minghui Wang ,Frederick R Maxfield ,Wayne W Poon ,Alison M Goate

Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD

MAPT 外显子 2 和外显子 10 剪接的失调协调是 PSP 和 AD 中不同 tau 病理的基础

Kathryn R Bowles, Derian A Pugh, Laura-Maria Oja, Benjamin M Jadow, Kurt Farrell, Kristen Whitney, Abhijeet Sharma, Jonathan D Cherry, Towfique Raj, Ana C Pereira, John F Crary, Alison M Goate

APOE4 confers transcriptomic and functional alterations to primary mouse microglia

APOE4 导致小鼠原代小胶质细胞发生转录组和功能改变

Saima I Machlovi, Sarah M Neuner, Brittany M Hemmer, Riana Khan, Yiyuan Liu, Min Huang, Jeffrey D Zhu, Joseph M Castellano, Dongming Cai, Edoardo Marcora, Alison M Goate

Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation

星形胶质细胞分泌的磷脂酰肌醇蛋白聚糖-4 驱动 APOE4 依赖的 tau 过度磷酸化

Sivaprakasam R Saroja, Kirill Gorbachev, Tcw Julia, Alison M Goate, Ana C Pereira

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids

ELAVL4、剪接和谷氨酸能功能障碍先于MAPT突变脑类器官中的神经元丢失

Kathryn R Bowles,M Catarina Silva,Kristen Whitney,Taylor Bertucci,Joshua E Berlind,Jesse D Lai,Jacob C Garza,Nathan C Boles,Sidhartha Mahali,Kevin H Strang,Jacob A Marsh,Cynthia Chen,Derian A Pugh,Yiyuan Liu,Ronald E Gordon,Susan K Goderie,Rebecca Chowdhury,Steven Lotz,Keith Lane,John F Crary,Stephen J Haggarty,Celeste M Karch,Justin K Ichida,Alison M Goate,Sally Temple

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

移植到小鼠大脑中的人类 iPSC 衍生星形胶质细胞会因淀粉样β蛋白斑块而发生形态变化

Pranav Preman #, Julia Tcw #, Sara Calafate, An Snellinx, Maria Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison M Goate, Bart De Strooper, Amaia M Arranz6

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

乙酰化 tau 抑制分子伴侣介导的自噬并促进小鼠 tau 病理传播

Benjamin Caballero #, Mathieu Bourdenx #, Enrique Luengo, Antonio Diaz, Peter Dongmin Sohn, Xu Chen, Chao Wang, Yves R Juste, Susanne Wegmann, Bindi Patel, Zapporah T Young, Szu Yu Kuo, Jose Antonio Rodriguez-Navarro, Hao Shao, Manuela G Lopez, Celeste M Karch, Alison M Goate, Jason E Gestwicki, Bra